Fungicidal VS. Fungistatic

Fungistatic drugs can only inhibit growth, keeping the fungal pathogens at bay without ever fully eliminating them.4 Fungicidal drugs, however, actively work to kill fungal pathogens.5

Product Drug
of Action
Formulation Dosage
GEL 2%
Allylamine Fungicidal T. rubrum
T. mentagrophytes
E. floccosum
Once daily for
2 weeks
Azole Fungistatic4 T.rubrum
Cream Once daily for
2 weeks
Azole Fungistatic4 T.rubrum
Foam Once daily for
4 weeks

There have been no comparative clinical trials conducted between these products or active ingredients.

Because azoles have seen widespread clinical use, fungal pathogens have built a resistance to them over time.10 But NAFTIN GEL 2% is an allylamine, which means it is chemically distinct from azole-based antifungal agents.1 Fungal resistance to allylamines has not been observed in clinical use.1,10

The #1 Prescribed Brand for Interdigital Tinea Pedis2

Low-alcohol formulation for 0.4% incidence of burning2*

Reservoir with active ingredient remains 4 weeks after treatment3

Statistically significant cure rates with once-daily, 2-week dosing12

Proven effective and safe fungicidal allylamine1

*NAFTIN GEL 2% has a lower incidence of burning sensation compared with NAFTIN GEL 1%11

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INDICATIONS AND USAGE: NAFTIN GEL 2% is an allylamine antifungal indicated for the treatment of interdigital tinea pedis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in patients 12 years of age and older.


ADVERSE REACTIONS: In clinical trials with NAFTIN GEL 2%, the most common adverse reactions (2%) were application site reactions.

WARNINGS AND PRECAUTIONS: If redness or irritation develops with the use of NAFTIN GEL 2%, treatment should be discontinued.

Please click here for full Prescribing Information about NAFTIN GEL 2%.

REFERENCES: 1. Vlahovic TC. Choosing the right vehicle. Podiatr Manage. June/July 2008;209-214. 2. Data on file, Sebela Pharmaceuticals. 3. Naftin Gel 2%. Package insert. Sebela Pharmaceuticals; 2020. 4. Graybill JR, Burgess DS, Hardin TC. Key issues concerning fungistatic versus fungicidal drugs. Eur J Clin Microbiol Infect Dis. 1997;16(1):42-50. 5. Plaum S, Verma A, Fleischer AB, Olayinka B, Hardas B. Detection and relevance of naftifine hydrochloride in the stratum corneum up to four weeks following the last application of naftifine cream or gel 2%. J Drugs Dermatol. 2013;12(9):1004-1008. 6. Stein Gold L, Parish L, Vlahovic T, Kircik L, et al. Efficacy and safety of naftifine HCL Gel 2% in the treatment of interdigital and moccasin type tinea pedis: pooled results from two multicenter, randomized, double-blind, vehicle-controlled trials. J Drugs Dermatol. 2013;12(8):911-918. 7. Brennan B, Leyden JJ. Overview of topical therapy for common superficial fungal infections and the role of new topical agents. J Am Acad Dermatol. 1997;36:S3-S8. 8. NAFTIN 2% Co-Pay Savings Offer. Sebela Pharmaceuticals, 2023. 9.  Parish LC, Parish JL, Routh HB, et al. A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis. J Drugs Dermatol. November 2011;10(11):1282-1288. 10. Parish LC, Parish JL, Routh HB, et al. A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol. October 2011;10(10):1142-1147. 11. Robbins CM, Elston DM. Tinea pedis treatment & management. Updated September 11, 2020. Accessed December 14, 2022. 12. Phillips, RM, Rosen T. Topical antifungal agents. Allylamines and benzylamines. In: Wolverton, SE, ed. Comprehensive Dermatologic Drug Therapy. 3rd ed. Elsevier Inc. Ebook; 2013:460-472. 13. IQVIA. National Prescription Audit Report. October 2022.