Advantages of NAFTIN® (Naftifine HCl) 2% aqueous-based, gel formulation1

The choice of a rapid-drying, non-greasy gel may enhance patient compliance7

  • Treating interdigital tinea pedis can be a challenge because the warm, moist environment of feet cramped in shoes provides the ideal environment for fungi8
  • Aqueous-based gels, like NAFTIN 2%, have excellent penetration properties and a drying effect that is advantageous for interdigital spaces that tend to stay moist7
  • A non-greasy gel may also be preferable in areas covered by socks and shoes7
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NAFTIN® (Naftifine HCl) Gel, 2%


NAFTIN GEL, 2% is an allylamine antifungal indicated for the treatment of interdigital tinea pedis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in patients 12 years of age and older.


In clinical trials with NAFTIN Gel, 2%, the most common adverse reactions (2%) were application site reactions.


If redness or irritation develops with the use of NAFTIN Gel, 2%, treatment should be discontinued.

Please click here for NAFTIN full prescribing information

References: 1. NAFTIN® Gel (Naftifine HCI), 2% Prescribing Information. Greensboro, NC: Merz Pharmaceuticals, LLC; October 2014. 2. Brennan B, Leyden JJ. Overview of topical therapy for common superficial fungal infections and the role of new topical agents. J Am Acad Dermatol. 1997;36:S3-S8. 3. NAFTIN 2% Co-Pay Savings Offer. Sebela Pharmaceuticals Inc., January 2017. 4. Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations. US Food and Drug Administration/Center for Drug Evaluation and Research website. Accessed February 22, 2016. 2015. 5. Parish LC, Parish JL, Routh HB, et al. A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis. J Drugs Dermatol. November 2011;10(11):1282-1288. 6. Parish LC, Parish JL, Routh HB, et al. A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol. October 2011;10(10):1142-1147. 7. Vlahovic TC. Choosing the right vehicle. Podiatry management. June/July 2008;209-218. 8. Robbins CM, Elston DM. Tinea pedis treatment & management. Medscape Web site. Updated November 19, 2015. Accessed February 22, 2016. 9. Phillips, RM, Rosen T. Topical antifungal agents. Allylamines and benzylamines. In: Wolverton, SE, ed. Comprehensive Dermatologic Drug Therapy. 3rd ed. Elsevier Inc. Ebook; 2013:460-472.