How NAFTIN GEL 2% works


Illustration of infected skin layers showing Naftin Gel 2% penetrating and forming a reservoir within the layers of the stratum corneum.

Before Treatment: There is a fungal infection within the layers of the stratum corneum. The deeper layers of epidermis are unaffected.

Period of Treatment, Days 1 through 14: Naftin Gel 2% applied to skin surface penetrates through all layers of the stratum corneum. The deeper layers of epidermis remain unaffected.

Still Working, Week 3: Naftin Gel 2% reservoir remains within the layers of the stratum corneum.

Still Working, Weeks 4 through 6: Naftin Gel 2% reservoir remains within the layers of the stratum corneum.

  • NAFTIN GEL 2% is delivered deep through all layers of the stratum corneum5
  • The reservoir of NAFTIN GEL 2% provides continuous fungicidal exposure to dermatophytes for at least 4 weeks after stopping treatment5
  • In a skin retention study, naftifine was present in tape strips sampled 28 days after the last drug application5
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INDICATIONS AND USAGE: NAFTIN GEL 2% is an allylamine antifungal indicated for the treatment of interdigital tinea pedis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in patients 12 years of age and older.


ADVERSE REACTIONS: In clinical trials with NAFTIN GEL 2%, the most common adverse reactions (2%) were application site reactions.

WARNINGS AND PRECAUTIONS: If redness or irritation develops with the use of NAFTIN GEL 2%, treatment should be discontinued.

Please click here for full Prescribing Information about NAFTIN GEL 2%.

REFERENCES: 1. Vlahovic TC. Choosing the right vehicle. Podiatr Manage. June/July 2008;209-214. 2. Data on file, Sebela Pharmaceuticals. 3. Naftin Gel 2%. Package insert. Sebela Pharmaceuticals; 2020. 4. Graybill JR, Burgess DS, Hardin TC. Key issues concerning fungistatic versus fungicidal drugs. Eur J Clin Microbiol Infect Dis. 1997;16(1):42-50. 5. Plaum S, Verma A, Fleischer AB, Olayinka B, Hardas B. Detection and relevance of naftifine hydrochloride in the stratum corneum up to four weeks following the last application of naftifine cream or gel 2%. J Drugs Dermatol. 2013;12(9):1004-1008. 6. Stein Gold L, Parish L, Vlahovic T, Kircik L, et al. Efficacy and safety of naftifine HCL Gel 2% in the treatment of interdigital and moccasin type tinea pedis: pooled results from two multicenter, randomized, double-blind, vehicle-controlled trials. J Drugs Dermatol. 2013;12(8):911-918. 7. Brennan B, Leyden JJ. Overview of topical therapy for common superficial fungal infections and the role of new topical agents. J Am Acad Dermatol. 1997;36:S3-S8. 8. NAFTIN 2% Co-Pay Savings Offer. Sebela Pharmaceuticals, 2023. 9.  Parish LC, Parish JL, Routh HB, et al. A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis. J Drugs Dermatol. November 2011;10(11):1282-1288. 10. Parish LC, Parish JL, Routh HB, et al. A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol. October 2011;10(10):1142-1147. 11. Robbins CM, Elston DM. Tinea pedis treatment & management. Updated September 11, 2020. Accessed December 14, 2022. 12. Phillips, RM, Rosen T. Topical antifungal agents. Allylamines and benzylamines. In: Wolverton, SE, ed. Comprehensive Dermatologic Drug Therapy. 3rd ed. Elsevier Inc. Ebook; 2013:460-472. 13. IQVIA. National Prescription Audit Report. October 2022.